(-)-JJ-450, CAS [[1998094-23-7]] Preis auf Anfrage

Produktübersicht

• Artikelname: (-)-JJ-450, CAS [[1998094-23-7]] Preis auf Anfrage
• Artikelnummer: BYT-ORB3136157
• Hersteller Artikelnummer: orb3136157
• Alternativnummer: BYT-ORB3136157-10, BYT-ORB3136157-50
• Hersteller: Biorbyt
• Kategorie: Biochemikalien

Produktbeschreibung

(-)-JJ-450 is a non-competitive antagonist targeting the androgen receptor (AR). It is more effective than (+)-JJ-450 in inhibiting androgen-induced AR activity, while (+)-JJ-450 inhibits AR via a mechanism distinct from Enzalutamide (MDV3100), possibly targeting the ligand-binding domain (LBD) of AR. (-)-JJ-450 inhibits transcriptional activity of both wild-type AR and the mutant ARF876L by suppressing AR nuclear translocation and promoting intranuclear degradation of unbound AR. This compound can be utilized in research focusing on castration-resistant prostate cancer (CRPC) that is resistant to Enzalutamide.

Produkteigenschaften

• Molekulargewicht: 372.86
• CAS Nummer: [1998094-23-7]
• Formel: C21H22ClFN2O
• Target-Kategorie: Androgen Receptor