MAPK-IN-5 is a potent inhibitor of MAPK, with an IC50 value of 1.35 µM in HeLa cells. It induces ROS-mediated DNA damage and mitochondrial apoptosis (apoptosis) via the MAPK pathway. MAPK-IN-5 significantly inhibits colony formation in HeLa cells, reduces viable cell numbers, suppresses cell migration, and arrests the cell cycle at the G2/M phase. It is applicable in cervical cancer research.
Molekulargewicht:
594.58
CAS Nummer:
[2579683-39-7]
Formel:
C30H29F3N6O4
Target-Kategorie:
Apoptosis,Caspase,ROS,PARP,Bcl-2 Family,p38 MAPK
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