DeFer-2 is a ferritin PROTAC degrader (Kd= 17.1 µM). It triggers the degradation of ferritin leading to the accumulation of free iron ions and an increase in ROS, which subsequently initiates caspase 3-GSDME mediated pyroptosis in cancer cells. DeFer-2 significantly inhibits tumor growth and extends the survival of mice with subcutaneous B16F10 tumors, and it is useful for melanoma research.
Molekulargewicht:
780.11
CAS Nummer:
[3058911-16-0]
Formel:
C44H69N5O5S
Target-Kategorie:
PROTACs,ROS,Caspase,Pyroptosis
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
