M4 mAChR Modulator-2, CAS [[3062458-27-6]] Preis auf Anfrage

Produktübersicht

• Artikelname: M4 mAChR Modulator-2, CAS [[3062458-27-6]] Preis auf Anfrage
• Artikelnummer: BYT-ORB3136618
• Hersteller Artikelnummer: orb3136618
• Alternativnummer: BYT-ORB3136618-10, BYT-ORB3136618-50
• Hersteller: Biorbyt
• Kategorie: Biochemikalien

Produktbeschreibung

M4mAChRModulator-2 is an orally active and selective positive allosteric modulator (PAM) of the M4 muscarinic acetylcholine receptor (M4mAChR) capable of crossing the blood-brain barrier, with an EC50 of 513 nM. It demonstrates high target selectivity, showing minimal affinity and low inhibition rates for non-target receptors (D1R/D2R/D3R, 5-HT subtypes, kappa/delta/µ opioid receptors, H1, M1/M2), while specifically binding to M4mAChR with a Ki of 377 nM and an inhibition rate of 62.8%. Additionally, M4mAChRModulator-2 can reverse the hyperlocomotion induced by Dizocilpine (MK-801) in mice and is applicable for schizophrenia research.

Produkteigenschaften

• Molekulargewicht: 441.50
• CAS Nummer: [3062458-27-6]
• Formel: C26H24FN5O
• Target-Kategorie: AChR