SOS1-IN-21, CAS [[2767633-04-3]] Preis auf Anfrage

Produktübersicht

• Artikelname: SOS1-IN-21, CAS [[2767633-04-3]] Preis auf Anfrage
• Artikelnummer: BYT-ORB3136657
• Hersteller Artikelnummer: orb3136657
• Alternativnummer: BYT-ORB3136657-10, BYT-ORB3136657-50
• Hersteller: Biorbyt
• Kategorie: Biochemikalien

Produktbeschreibung

SOS1-IN-21 is an orally active inhibitor of son of Sevenless 1 (SOS1) with an IC50 value of 15 nM. As a guanine nucleotide exchange factor (GEF), SOS1 activates KRAS by facilitating the conversion of GDP to GTP. SOS1-IN-21 demonstrates potent antiproliferative activity, with IC50 values of 16 nM for NCI-H358 cells and 17 nM for Mia Paca-2 cells. It exhibits significant antitumor activity in Mia Paca-2 xenograft models and is useful for researching KRAS-mutated tumors, such as pancreatic cancer.

Produkteigenschaften

• Molekulargewicht: 493.52
• CAS Nummer: [2767633-04-3]
• Formel: C25H30F3N3O4
• Target-Kategorie: Raf