GNF4877 is a potent DYRK1A and GSK3beta inhibitor with IC50s of 6 nM and 16 nM, respectively, which leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased beta-cell proliferation (EC50 of 0.66 µM for mouse beta (R7T1) cells)
Molekulargewicht:
494.518088579178
CAS Nummer:
[2041073-22-5]
Formel:
C25H27FN6O4
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten