FLAER iFluor488

Artikelnummer: CBT-3105115
Artikelname: FLAER iFluor488
Artikelnummer: CBT-3105115
Hersteller Artikelnummer: 3105115
Alternativnummer: CBT-3105115-100,CBT-3105115-50UG,CBT-3105115-50
Hersteller: Caprico Biotechnologies
Wirt: Mouse
Kategorie: Antikörper
Spezies Reaktivität: Mammal
Konjugation: iFluor488
FLAER is a unique protein that binds tightly and specifically to mammalian glycol-phosphatidylinositol (GPI) anchored proteins on the cell surface. In healthy individuals, FLAER binds to essentially all GPI-expressing human lymphocytes, monocytes and gra

FLAER is a unique protein that binds tightly and specifically to mammalian glycol-phosphatidylinositol (GPI) anchored proteins on the cell surface. In healthy individuals, FLAER binds to essentially all GPI-expressing human lymphocytes, monocytes and granulocytes. White blood cells in a PNH patient losses expression of the GPI anchored cell-surface protein and FLAER fails to bind to lymphocytes, monocytes and granulocytes in a PNH patient. It is possible to detect the PNH clones by flow cytometry using fluorescently labeled antibodies to other GPI-linked proteins such as CD59 and CD55. But these antibodies have low binding affinity to GPI anchored surface antigen and confirmation of the presence of PNH clones was difficult as they often showed false negative results. Due to the high binding affinity of FLAER to the GPI anchor itself, only PNH cells, which lack the GPI anchored surface protein, will be negative and thus provides confirmatory results of the presence of PNH clones.

Klonalität: Monoclonal
Puffer: PBS pH 7.2, 0.2% (w/v) BSA, 0.09% (w/v) sodium azide
Reinheit: >95%
Formel: PBS, pH7.2, 0.09% NaN3 and 0.2% (w/v) BSA
Target-Kategorie: Mammalian GPI Protein
Antibody Type: Recombinant Monoclonal Antibody
Lymphocytes gated PBMCs stained with FLAER iFluor488 (RED); Lymphocytes gated PBMCs are used as FMO control (BLUE).
3105115