MEK4 (F194)Rabbit pAb, Polyclonal

Produktübersicht

• Artikelname: MEK4 (F194)Rabbit pAb, Polyclonal
• Artikelnummer: EBT-EA362
• Hersteller Artikelnummer: EA362
• Alternativnummer: EBT-EA362-50, EBT-EA362-100
• Hersteller: ELK Biotechnology
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: WB
• Spezies Reaktivität: Human, Mouse, Rat
• Immunogen: Recombinant Protein
• Alternative Synonym: JNK activating kinase 1, JNKK, JNKK1, MAP kinase kinase 4, MAP2K4, MAPK/ERK kinase 4, MAPKK 4, MAPKK4, MKK4, PRKMK4, SAPK/ERK kinase 1, SEK1, SERK1

Produktbeschreibung

SAPK/Erk kinase (SEK1), also known as MEK4 or MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflammatory cytokines . Activation of SEK1 occurs through MEKK phosphorylation of serine and threonine residues at positions 257 and 261, respectively. Like MEK, SEK is a dual-specificity protein kinase that phosphorylates SAPK/JNK at a conserved T*PY* site in its activation loop . Phosphorylation by Akt at Ser80 inhibits SEK1 and suppresses stress-activated signal transduction .

Produkteigenschaften

• Klonalität: Polyclonal
• Konzentration: 1mg/mL
• Molekulargewicht: 44kDa
• NCBI: 6416
• UniProt: P45985

Anwendungsbeschreibung

• Application Verdünnung: WB 1:1,000-2,000

Bilder

Western blot analysis of 1) A431 Cell Lysate, 2) Mouse Brain Tissue Lysate , 3) Rat Brain Tissue Lysate using MEK4(EA362)Rabbit pAb diluted at 1:2000.