Recombinant Human ACE-2 (C-mFc)

Produktübersicht

• Artikelname: Recombinant Human ACE-2 (C-mFc)
• Artikelnummer: EBT-EPT272
• Hersteller Artikelnummer: EPT272
• Alternativnummer: EBT-EPT272-50
• Hersteller: ELK Biotechnology
• Kategorie: Proteine/Peptide
• Alternative Synonym: Angiotensin-Converting Enzyme 2, ACE-Related Carboxypeptidase, Angiotensin-Converting Enzyme Homolog, ACEH, Metalloprotease MPROT15, ACE2

Produktbeschreibung

Recombinant Human Angiotensin-Converting Enzyme 2 is produced by our Mammalian expression system and the target gene encoding Gln18-Ser740 is expressed with a mFc tag at the C-terminus.

Produkteigenschaften

• Molekulargewicht: Molecular weight: 110 KDa. Apparent molecular weight: 110-140 KDa, reducing conditions
• UniProt: Q9BYF1
• Reinheit: Greater than 95% as determined by reducing SDS-PAGE.

Anwendungsbeschreibung

• Anwendungsbeschreibung: Endotoxin: Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. Biological activity: Immobilized 2019-nCoV S1 Protein (CatDRA35)at 10µg/ml (100µl/well) can bind Human ACE-2-mFc(CatC06A). The ED50 of Human ACE-2-mFc(CatC06A) is 45.11 ng/ml. Background: Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor dont inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function