The antiserum was produced against synthesized peptide derived from human HDAC8 around the phosphorylation site of Ser39. AA range:5-54
Alternative Synonym:
HDAC8, HDACL1, CDA07, Histone deacetylase 8, HD8
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009],
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Western Blot analysis of various cells using Phospho-HDAC8 (S39) Polyclonal Antibody diluted at 1:500
Western Blot analysis of VEC cells using Phospho-HDAC8 (S39) Polyclonal Antibody diluted at 1:500
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using HDAC8 (Phospho-Ser39) Antibody. The picture on the right is blocked with the phospho peptide.
Western blot analysis of lysates from NIH/3T3 cells, using HDAC8 (Phospho-Ser39) Antibody. The lane on the right is blocked with the phospho peptide.
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