Cell cycle checkpoint protein RAD1 (hRAD1,EC 3.1.11.2,DNA repair exonuclease rad1 homolog,Rad1-like DNA damage checkpoint protein)
This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jan 2009],
