The antiserum was produced against synthesized peptide derived from human STAT2 around the phosphorylation site of Tyr690. AA range:656-705
Alternative Synonym:
STAT2, Signal transducer and activator of transcription 2, p113
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010],
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Western blot analysis of lysates from Hela cells treated with IFN 2500U/ml 30 , using Stat2 p-Thr690 Antibody. Primary Antibody was diluted at 1:1000 4 over night,secondary antibody(Immunoway cat:RS0002)was diluted at 1:10000, 37 1hour.
Western blot analysis of Stat2 (phospho Tyr690) Polyclonal Antibody, using Hela,Jurkat cell treated or untreated with IFN 2500U/ml 30, 4 over night, secondary antibody(cat: RS0002 was diluted at 1:10000, 37 1hour.
Western Blot analysis of various cells using Phospho-Stat2 (Y690) Polyclonal Antibody
Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using STAT2 (Phospho-Tyr690) Antibody
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