IGF-IR (phospho Tyr1161) rabbit pAb, Rabbit, Polyclonal

Produktübersicht

• Artikelname: IGF-IR (phospho Tyr1161) rabbit pAb, Rabbit, Polyclonal
• Artikelnummer: EBT-ES1515
• Hersteller Artikelnummer: ES1515
• Alternativnummer: EBT-ES1515-50, EBT-ES1515-100
• Hersteller: ELK Biotechnology
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: ELISA, IF, IHC, WB
• Spezies Reaktivität: Human, Mouse, Rat
• Immunogen: Synthesized phospho-peptide around the phosphorylation site of human IGF-IR (phospho Tyr1161)
• Alternative Synonym: IGF1R, Insulin-like growth factor 1 receptor, Insulin-like growth factor I receptor, IGF-I receptor, CD antigen CD221, INSR, Insulin receptor, IR, CD antigen CD220

Produktbeschreibung

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014],

Produkteigenschaften

• Klonalität: Polyclonal
• Konzentration: 1 mg/ml
• Molekulargewicht: pro: 155kD, recetor beta: 95kD
• NCBI: 3480
• UniProt: P08069

Anwendungsbeschreibung

• Application Verdünnung: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.

Bilder

Immunohistochemical analysis of paraffin-embedded Human breast cancer. Antibody was diluted at 1:100(4 overnight). High-pressure and temperature Tris-EDTA,pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.

Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using IGF1R (Phospho-Tyr1161) Antibody

Immunofluorescence analysis of HuvEc cell, using IGF1R (Phospho-Tyr1161) Antibody. The lane on the right is blocked with the IGF1R (Phospho-Tyr1161) peptide.

Immunohistochemistry analysis of paraffin-embedded human breast cancer, using IGF1R (Phospho-Tyr1161) Antibody. The picture on the right is blocked with the IGF1R (Phospho-Tyr1161) peptide.