IGF2R (Phospho-Ser2484) rabbit pAb, Rabbit, Polyclonal

Produktübersicht

• Artikelname: IGF2R (Phospho-Ser2484) rabbit pAb, Rabbit, Polyclonal
• Artikelnummer: EBT-ES15518
• Hersteller Artikelnummer: ES15518
• Alternativnummer: EBT-ES15518-50, EBT-ES15518-100
• Hersteller: ELK Biotechnology
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: IF, IHC, WB
• Spezies Reaktivität: Human, Mouse, Rat
• Immunogen: Synthesized peptide derived from human IGF2R (Phospho-Ser2484)
• Alternative Synonym: Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor,CI-MPR,M6PR,300 kDa mannose 6-phosphate receptor,MPR 300,Insulin-like growth factor 2 receptor,Insulin-like growth factor II receptor,IGF-II receptor,M6P/IGF2 receptor,M6P/IGF2R,CD antigen CD222)

Produktbeschreibung

This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele, however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015],

Produkteigenschaften

• Klonalität: Polyclonal
• Konzentration: 1 mg/ml
• Molekulargewicht: 300kD
• NCBI: 3482
• UniProt: P11717

Anwendungsbeschreibung

• Application Verdünnung: IHC-p 1:50-200, WB 1:500-2000

Bilder

Immunohistochemical analysis of paraffin-embedded human Gastric adenocarcinoma. 1, Antibody was diluted at 1:200(4 overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).