Abl1/2 rabbit pAb, Rabbit, Polyclonal

Produktübersicht

• Artikelname: Abl1/2 rabbit pAb, Rabbit, Polyclonal
• Artikelnummer: EBT-ES1576
• Hersteller Artikelnummer: ES1576
• Alternativnummer: EBT-ES1576-50, EBT-ES1576-100
• Hersteller: ELK Biotechnology
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: ELISA, IF, IHC, WB
• Spezies Reaktivität: Human, Mouse
• Immunogen: The antiserum was produced against synthesized peptide derived from human c-Abl. AA range:406-455
• Alternative Synonym: ABL1, ABL, JTK7, Tyrosine-protein kinase ABL1, Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein kinase 1, Proto-oncogene c-Abl, p150, ABL2, ABLL, ARG, Abelson tyrosine-protein kinase 2, Abelson murine leukemia vira

Produktbeschreibung

This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9,22) translocation that results in a fusion with the 5 end of the breakpoint cluster region gene (BCR, MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [pr

Produkteigenschaften

• Klonalität: Polyclonal
• Konzentration: 1 mg/ml
• Molekulargewicht: 125(200kd BCR-ABL complex)
• NCBI: 25
• UniProt: P00519

Anwendungsbeschreibung

• Application Verdünnung: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

Bilder

Western Blot analysis of various cells using Abl1/2 Polyclonal Antibody

Western Blot analysis of K562 cells using Abl1/2 Polyclonal Antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using c-Abl Antibody. The picture on the right is blocked with the synthesized peptide.

Western blot analysis of lysates from RAW264.7 cells, using c-Abl Antibody. The lane on the right is blocked with the synthesized peptide.