CD130/gp130 (Phospho-Ser782) rabbit pAb, Rabbit, Polyclonal

Produktübersicht

• Artikelname: CD130/gp130 (Phospho-Ser782) rabbit pAb, Rabbit, Polyclonal
• Artikelnummer: EBT-ES17738
• Hersteller Artikelnummer: ES17738
• Alternativnummer: EBT-ES17738-50, EBT-ES17738-100
• Hersteller: ELK Biotechnology
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: IF, IHC, WB
• Spezies Reaktivität: Human, Mouse
• Immunogen: Synthesized peptide derived from human CD130/gp130 (Phospho-Ser782)
• Alternative Synonym: Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta,IL-6R subunit beta,IL-6R-beta,IL-6RB,CDw130,Interleukin-6 signal transducer,Membrane glycoprotein 130,gp130,Oncostatin-M receptor subunit alpha,CD antigen CD130)

Produktbeschreibung

The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014],

Produkteigenschaften

• Klonalität: Polyclonal
• Konzentration: 1 mg/ml
• Molekulargewicht: 130kD
• NCBI: 3572
• UniProt: P40189

Anwendungsbeschreibung

• Application Verdünnung: IHC-p 1:50-200, WB 1:500-2000

Bilder

Immunohistochemical analysis of paraffin-embedded human Breast cancer. 1, Antibody was diluted at 1:200(4 overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).