The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Western blot analysis of various lysates, primary antibody was diluted at 1:1000, 4 over night, secondary antibody(cat: RS23920)was diluted at 1:10000, 37 1hour.
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