Synthesized peptide derived from human Smad7 (Acetyl Lys70)
Alternative Synonym:
Mothers against decapentaplegic homolog 7 (MAD homolog 7,Mothers against DPP homolog 7,Mothers against decapentaplegic homolog 8,MAD homolog 8,Mothers against DPP homolog 8,SMAD family member 7,SMAD 7,Smad7,hSMAD7)
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010],
Immunohistochemical analysis of paraffin-embedded human Squamous cell carcinoma of lung. 1, Antibody was diluted at 1:200(4 overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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