The antiserum was produced against synthesized peptide derived from the C-terminal region of human DBI. AA range:38-87
Alternative Synonym:
DBI, Acyl-CoA-binding protein, ACBP, Diazepam-binding inhibitor, DBI, Endozepine, EP
This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoform
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Western Blot analysis of MCF7, U251, mouse liver, mouse kidney cells using ACBP Polyclonal Antibody. Secondary antibody(catalog:RS0002) was diluted at 1:20000
Western blot analysis of lysate from MCF7 cells, using DBI Antibody.
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