The antiserum was produced against synthesized peptide derived from human AKAP13. AA range:721-770
Alternative Synonym:
AKAP13, BRX, HT31, LBC, A-kinase anchor protein 13, AKAP-13, AKAP-Lbc, Breast cancer nuclear receptor-binding auxiliary protein, Guanine nucleotide exchange factor Lbc, Human thyroid-anchoring protein 31, Lymphoid blast crisis oncogene, LBC
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addi
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Immunohistochemistry analysis of paraffin-embedded human heart tissue, using AKAP13 Antibody. The picture on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from Jurkat and A549 cells, using AKAP13 Antibody. The lane on the right is blocked with the synthesized peptide.
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