Cortactin rabbit pAb, Rabbit, Polyclonal

Produktübersicht

• Artikelname: Cortactin rabbit pAb, Rabbit, Polyclonal
• Artikelnummer: EBT-ES4755
• Hersteller Artikelnummer: ES4755
• Alternativnummer: EBT-ES4755-50, EBT-ES4755-100
• Hersteller: ELK Biotechnology
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: ELISA, IF, IHC, WB
• Spezies Reaktivität: Human, Monkey, Mouse, Rat
• Immunogen: The antiserum was produced against synthesized peptide derived from mouse Cortactin. AA range:441-490
• Alternative Synonym: CTTN, EMS1, Src substrate cortactin, Amplaxin, Oncogene EMS1

Produktbeschreibung

cortactin(CTTN) Homo sapiens This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010],

Produkteigenschaften

• Klonalität: Polyclonal
• Konzentration: 1 mg/ml
• Molekulargewicht: 80kD
• NCBI: 13043
• UniProt: Q14247

Anwendungsbeschreibung

• Application Verdünnung: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

Bilder

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using Cortactin Antibody. The picture on the right is blocked with the synthesized peptide.

Western blot analysis of lysates from LOVO cells, using Cortactin Antibody. The lane on the right is blocked with the synthesized peptide.