The antiserum was produced against synthesized peptide derived from human BCL-XL around the phosphorylation site of Ser62. AA range:28-77
Alternative Synonym:
BCL2L1, BCL2L, BCLX, Bcl-2-like protein 1, Bcl2-L-1, Apoptosis regulator Bcl-X
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015],
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using BCL-XL (Phospho-Ser62) Antibody. The picture on the right is blocked with the phospho peptide.
Western blot analysis of lysates from 293 cells treated with UV and MDA-MB-435 cells treated with UV, using BCL-XL (Phospho-Ser62) Antibody.
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