The antiserum was produced against synthesized peptide derived from human Claudin 1. AA range:162-211
Alternative Synonym:
CLDN1, CLD1, SEMP1, Claudin-1, Senescence-associated epithelial membrane protein
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008],
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Western blot analysis of lysates from HeLa cells, treated with Hu 2nM 24h, using Claudin 1 Antibody. The lane on the right is blocked with the synthesized peptide.
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