The antiserum was produced against synthesized peptide derived from human Gab2. AA range:589-638
Alternative Synonym:
GAB2, KIAA0571, GRB2-associated-binding protein 2, GRB2-associated binder 2, Growth factor receptor bound protein 2-associated protein 2, pp100
GRB2 associated binding protein 2(GAB2) Homo sapiens This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009],
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Western blot analysis of lysates from Jurkat cells, treated with TNF 2500U/ml 30, using Gab2 Antibody. The lane on the right is blocked with the synthesized peptide.
Western blot analysis of the lysates from RAW264.7cells using Gab2 antibody.
Immunohistochemical analysis of paraffin-embedded human small intestinal carcinoma tissue. 1,primary Antibody was diluted at 1:200(4 overnight). 2, Sodium citrate pH 6.0 was used for antigen retrieval(>98C,20min). 3,Secondary antibody was diluted at 1:200
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