Synthesized acetyl-peptide derived from human p300 around the acetylation site of K1558.
Alternative Synonym:
EP300, P300, Histone acetyltransferase p300, p300 HAT, E1A-associated protein p300
E1A binding protein p300(EP300) Homo sapiens This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008],
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Western blot analysis of HELA 293T using Acetyl-p300 (K1558/K1560) antibody. Antibody was diluted at 1:500. Secondary antibody(catalog:RS0002) was diluted at 1:20000
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