CAS Number: 138579-66-5Molecular Weight: 2198.1Salt Form: TFAPurity: >90%Sequence (3-letter): Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2Sequence (1-letter): GWTLNSAGYLLGPQQFFGLM-NH2Storage: -20 AC or belowGalantide is a chimeric peptide consisting of fragments of galanin and Substance P which acts as a reversible galanin receptor antagonist. The peptide antagonizes the galanin-mediated inhibition of the glucose-induced insulin secretion from mouse pancreatic islets in a dose-dependant manner (IC50 = 1.0 nM). It antagonizesA the galanin-induced increase in K+ conductance IC50 = 4 nM).References1) Lindskog S et al. The novel high-affinity antagonist galantide blocks the galanin-mediated inhibition of glucose-induced insulin secretion. Eur J Pharmacol. 1992,210(2):183-188.2) Mulvaney JM et al. Galantide distinguishes putative subtypes of galanin receptors in mudpuppy parasympathetic neurons. Eur J Pharmacol. 1995,287(1):97-100.
Tag:
1178
CAS Nummer:
[138579-66-5]
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