CAS Number: 129176-97-2Molecular Weight: 1667.7Salt Form: TFAPurity: >95%Sequence (3-letter): e-nicotinoyl-D-Lys-Pro-3Pal-Pro-(3 4Cl)D-Phe-Asn-D-Trp-Phe-D-Trp-Leu-Nle-NH2 (3Pal = 3-pyridylalanine)Sequence (1-letter): (e-nicotinoyl)kP(3Pal)P((3 4Cl)D)FNwFwL(Nle)-NH2Storage: -20 AC or belowSolubility: water (1 mg/mL)Spantide II is an undecapeptide substance P (SP) analog that is more potent as a substance P antagonist than spantide I and less effective in releasing histamine from mast cells. It is a neurokinin-1 receptor (NK-1R) antagonist that is used to control inflammation particularly in skin conditions and has negligible neurotoxicity.References1. Hakanson R. et al. (1990) a€Spantide II a novel tachykinin antagonist having high potency and low histamine-releasing effecta€ Regul. Pept. 31 (1): 75-82.2.Kincy-Cain T. and Bost K.L. (1996) a€Increased susceptibility of mice to Salmonella infection following in vivo treatment with the substance P antagonist spantide IIa€ J. Immunol. 157 (1): 255-264.3. Gerfen C.R. (1991) a€Substance P (neurokinin-1) receptor mRNA is selectively expressed in cholinergic neurons in the striatum and basal forebraina€ Brain Res. 556 (1): 165a€''170.
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[129176-97-2]
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