Furin Inhibitor II (Hexa-D-Arginine), CAS [[673202-67-0]]

Produktübersicht

• Artikelname: Furin Inhibitor II (Hexa-D-Arginine), CAS [[673202-67-0]]
• Artikelnummer: ECH-855-10-1MG
• Hersteller Artikelnummer: 855-10-1mg
• Alternativnummer: ECH-855-10-1MG
• Hersteller: Echelon Biosciences
• Kategorie: Molekularbiologie

Produktbeschreibung

CAS Number: A 673202-67-0Molecular Weight: 953.63Salt Form: TFAPurity: >96%Sequence (3-letter): D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-NH2Sequence (1-letter): rrrrrr-NH2Storage: -20 AC or belowSolubility: 20% acetonitrile/water 1 mg/mLFurin inhibitor II (Hexa-D-Arginine) as the name implies inhibits furin (Ki = 106 nM for purified furin). Furin is an enzyme belonging to the subtilisin-like proprotein convertase family which process precursor proteins into biologically active products.Representative substrates include von Willebrand factor TGFi-1 precursor MMP-1 gp160 proparathyroid hormone and proalbumin. Peptide contains all D-amino acids, also called Hexa-D-Arg or Hexa-D-Arginine or (D-Arg)6-NH2Results from a recent paper and preprint show the presence of a furin cleavage site on the spike protein of the SARS-CoV-2 which is required for membrane fusion and replication. Inhibition of furin activity can stop viral replication.References1. Cameron A. et al. (2000) a€Polyarginines Are Potent Furin Inhibitorsa€ J. Biol. Chem. 275: 36741-36749.2. Henrich S. et al. (2005) a€Proprotein Convertase Models based on the Crystal Structures of Furin and Kexin: Explanation of their Specificitya€ J. Mol. Biol. 345 (2): 211a€''227.

Produkteigenschaften

• Tag: 1269 1267 1268 172
• CAS Nummer: [673202-67-0]