Ac-Val-Ala-Asp-AFC (Caspase 1 (ICE) Substrate), CAS [[219137-85-6]]

Produktübersicht

• Artikelname: Ac-Val-Ala-Asp-AFC (Caspase 1 (ICE) Substrate), CAS [[219137-85-6]]
• Artikelnummer: ECH-860-12-25MG
• Hersteller Artikelnummer: 860-12-25mg
• Alternativnummer: ECH-860-12-25MG
• Hersteller: Echelon Biosciences
• Kategorie: Molekularbiologie

Produktbeschreibung

CAS Number: 219137-85-6Molecular Weight: 556.18Salt Form: N/APurity: >96%Sequence (3-letter): Ac-Val-Ala-Asp-AFCSequence (1-letter): Ac-VAD-AFCStorage: -20 AC or belowAc-Val-Ala-Asp-AFC is a fluorogenic substrate for Caspase 1. Caspase 1/Interleukin 1b converting enzyme (ICE) is a cysteine protease that cleaves specifically at aspartic acid. ICE converts inactive IL-1 beta precursor to a pro-inflammatory cytokine that mediates a wide range of immune and inflammatory response. ICE-related cysteine proteases are required for E1A-induced p53-dependent apoptosis in baby rat kidney (BRK) cells. Adenovirus E1B 19K protein which is a potent inhibitor of apoptosis inhibits activation of these proteases in BRK cells.Activity is quantified by release of free fluorescent 7-amino-4-trifluoromethylcoumarin (AFC) which excites at 395-400 nm and emits at 495-505 nm.

Produkteigenschaften

• Tag: 1208 1179
• CAS Nummer: [219137-85-6]