Ac-Asp-Met-Gln-Asp-AMC (Caspase 3 (Apopain) Substrate), CAS [[355137-38-1]]

Produktübersicht

• Artikelname: Ac-Asp-Met-Gln-Asp-AMC (Caspase 3 (Apopain) Substrate), CAS [[355137-38-1]]
• Artikelnummer: ECH-860-28-25MG
• Hersteller Artikelnummer: 860-28-25mg
• Alternativnummer: ECH-860-28-25MG
• Hersteller: Echelon Biosciences
• Kategorie: Molekularbiologie

Produktbeschreibung

CAS Number: 355137-38-1Molecular Weight: 706.23Salt Form: TFAPurity: >96%Sequence (3-letter): Ac-Asp-Met-Gln-Asp-AMCSequence (1-letter): Ac-DMQD-AMCStorage: -20 AC or belowAc-Asp-Met-Gln-Asp-AMC is a fluorogenic substrate for Caspase 3 (Apopain). Caspase 3 is a cysteine protease that is rapidly activated during apoptosis and that cleaves several substrates including poly(ADP-ribose) polymerase (PARP). Caspase 3 is activated by Caspases 8 9 and 10 and cleaves and activates caspase 6 and 7. Caspase 3 cleaves the amyloid precursor protein (APP) contributing to Amyloid beta formation and has been implicated in Alzheimera€(TM)s disease and proposed as a target for drug discovery. Ac-DMQD-AMC is reported to be a more specific caspase-3 substrate than Ac-DEVD-AMC.Activity is quantified by release of free fluorescent 7-amino-4-methylcoumarin (AMC) which excites at 360-380 nm and emits at 440-460 nm.References1. Talanian R.V. et al. (1997) a€Substrate Specificities of Caspase Family Proteasesa€ J. Biol. Chem. 272 (15): 9677a€''9682.2.Nagane M. et al. (1998) a€Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteasesa€ Proc. Natl. Acad. Sci. USA 95 (10): 5724a€''5729.3) Troy T. Rohn Elizabeth Head a€Caspases as Therapeutic Targets in Alzheimera€(TM)s Disease: Is It Time to a€Cuta€ to the Chase?a€ Int J Clin Exp Pathol. 2009, 2(2): 108a€''118.

Produkteigenschaften

• Tag: 1208 1179
• CAS Nummer: [355137-38-1]