Molecular Weight: 594.23 Salt Form: N/A Purity: >96% Sequence (3-letter): Ac-Ala-Glu-Val-Asp-pNA Sequence (1-letter): Ac-AEVD-pNA Storage: -20 AC or belowAc-Ala-Glu-Val-Asp-pNA is a colorimetric substrate for Caspase 3. Caspase 3 is a cysteine protease that is rapidly activated during apoptosis and that cleaves several substrates including poly(ADP-ribose) polymerase (PARP). Caspase 3 is activated by Caspases 8 9 and 10 and cleaves and activates caspase 6 and 7. Caspase 3 cleaves the amyloid precursor protein (APP) contributing to Amyloid beta formation and has been implicated in Alzheimera€(TM)s disease and proposed as a target for drug discovery.Activity is quantified by the release of p-nitroaniline which is measured by absorbance at 405 nm.References 1. Talanian R.V. et al. (1997) a€Substrate Specificities of Caspase Family Proteasesa€ J. Biol. Chem. 272 (15): 9677a€''9682.2.Nagane M. et al. (1998) a€Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteasesa€ Proc. Natl. Acad. Sci. USA 95 (10): 5724a€''5729.3) Troy T. Rohn Elizabeth Head a€Caspases as Therapeutic Targets in Alzheimera€(TM)s Disease: Is It Time to a€Cuta€ to the Chase?a€ Int J Clin Exp Pathol. 2009, 2(2): 108a€''118.
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