Molecular Weight: 727.27Salt Form: N/APurity: >96%Sequence (3-letter): Ac-Val-Glu-Ile-Asp-AFCSequence (1-letter): Ac-VEID-AFCStorage: -20 AC or belowSolubility: 20 mM in DMSO or DMFAc-VEID-AFC is a fluorogenic substrate for caspase 6 (Mch-2i). Caspase 6 is a cysteine protease involved in the execution phase of apoptosis mediating neuronal shrinkage. In addition it has important roles in neurodegenerative disorders such as Huntingtona€(TM)s Parkinsona€(TM)s and Alzheimera€(TM)s diseases. Caspase 6 cleaves the mutated huntintin protein and the amyloid precursor protein resulting in the aggregating protein fragments typical of Huntingtona€(TM)s and Alzheimera€(TM)s diseases respectively.Activity is quantified by release of free fluorescent 7-amino-4-trifluoromethylcoumarin (AFC) which excites at 395-400 nm and emits at 495-505 nm.References1. LeBlanc A. et al. (1999) a€Caspase-6 Role in Apoptosis of Human Neurons Amyloidogenesis and Alzheimera€(TM)s Diseasea€ J. Biol. Chem. 274: 23426-23436.2. Guo R-F. et al. (2000) a€Protective effects of anti-C5a in sepsis-induced thymocyte apoptosisa€ J. Clin. Invest. 106(10): 1271a€''1280.
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