SKI-178 (SPHK1 Inhibitor)

Produktübersicht

• Artikelname: SKI-178 (SPHK1 Inhibitor)
• Artikelnummer: ECH-B-0028
• Hersteller Artikelnummer: B-0028
• Alternativnummer: ECH-B-0028-10MG,ECH-B-0028-25MG
• Hersteller: Echelon Biosciences
• Kategorie: Molekularbiologie

Produktbeschreibung

SKI-178 is a selective inhibitor of sphingosine kinase 1 which is active in vitro and in vivo. SKI-178 is a competitive inhibitor of sphingosine binding to SPHK1 (Ki = 1.3 uM) and shows no inhibition of SPHK2 up to 25 uM. SKI-178 is cytotoxic to numerous cancer cell lines (MCF-7, A549, Panc-1, etc) at low to sub-micromolar concentrations.

Storage

-20 C

References

1) J.A. Hengst et al. ''Development of a sphingosine kinase 1 specific small-molecule inhibitor Bioorg. Med. Chem. Lett. 2010, 20, 7498-7502. doi: 10.1016/j.bmcl.2010.10.005 2) T.E. Dick et al. ''The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines J. Pharmacol. Exp. Ther. 2015, 352, 494-508. doi: 10.1124/jpet.114.219659

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Documents

Technical Data Sheet

Anwendungsbeschreibung

• Anwendungsbeschreibung: Categories: Biochemical Reagents. Related: Inhibitor, Sphingolipid. Ship 1 : Shipping Temp. Ship 2: Ambient Temperature