KP372-1 (Akt Inhibitor)

Produktübersicht

• Artikelname: KP372-1 (Akt Inhibitor)
• Artikelnummer: ECH-B-0102
• Hersteller Artikelnummer: B-0102
• Alternativnummer: ECH-B-0102-5MG
• Hersteller: Echelon Biosciences
• Kategorie: Molekularbiologie

Produktbeschreibung

KP372-1 directly inhibits the kinase activities of Akt, PDK1 and Flt3 (Fms-like tyrosine kinase 3), which are aberrantly activated in acute myelogenous leukemia (AML). It is a cell permeant inhibitor that decreases the colony-forming ability of AML cells (IC50 < 200 nM) with minimal cytoxic effects on normal hematopoietic progenitor cells. KP372-1 has also been shown to suppress cell proliferation and induce apoptosis in thyroid cancer cells and gliobastoma. Provided as a 1:1 mixture of regioisomers.

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Solubility

Water: insoluble, DMSO: 5 mg/mL

Storage

2-8oC. Stock solutions should be stored frozen (-20oC).

References

1) M. Mandal et al. The Akt Inhibitor KP372-1 Suppresses Akt Activity and Cell Proliferation and Induces Apoptosis in Thyroid Cancer Cells Br. J. Cancer, 2005, 92, 1899-1905. 2) Z. Zeng et al Simultaneous Inhibition of PDK1/AKT and Fms-Like Tyrosine Kinase 3 Signaling by a Small-Molecule KP372-1 Induces Mitochondrial Dysfunction and Apoptosis in Acute Myelogenous Leukemia. Cancer Res., 2006, 66, 3737-3746.

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Documents

Technical Data Sheet

Anwendungsbeschreibung

• Anwendungsbeschreibung: Categories: Biochemical Reagents. Related: Akt, Inhibitor. Ship 1 : Shipping Temp. Ship 2: Ambient Temperature