AS604850 (PI3-K gamma Inhibitor 2)

Produktübersicht

• Artikelname: AS604850 (PI3-K gamma Inhibitor 2)
• Artikelnummer: ECH-B-0302
• Hersteller Artikelnummer: B-0302
• Alternativnummer: ECH-B-0302-1MG,ECH-B-0302-5MG
• Hersteller: Echelon Biosciences
• Kategorie: Molekularbiologie

Produktbeschreibung

5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione (AS604850) is an inhibitor of PI 3-Kgamma with an IC50 = 250 nM. AS604850 is selective for the gamma-isoform (IC50: PI 3-Kalpha = 4.5 µM, PI 3-Kbeta, PI 3-Kdelta > 20 µM) and shows no notable activity against a wide array of protein kinases at 1 µM.

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Solubility

Water: insoluble, DMSO: 5 mg/mL

Storage

Store dry between 2-8oC. Stock solutions should be stored frozen (-20oC).

References

1) M. Camps et al. Blockade of PI3Kg suppresses joint inflammation and damage in mouse models of rheumatoid arthritis Nature Medicine, 2005, 11, 936-943.

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Documents

Technical Data Sheet

Anwendungsbeschreibung

• Anwendungsbeschreibung: Categories: Biochemical Reagents. Related: Inhibitor, PI3K. Ship 1 : Shipping Temp. Ship 2: Ambient Temperature