PI-103 is a selective inhibitor for the alpha-isoform of PI 3-Kinase (IC50: PI 3-Kalpha = 8 nM, PI 3-Kbeta = 88 nM, PI 3-Kdelta = 48 nM, PI 3-Kgamma = 150 nM). It is also inhibits DNA-PK (IC50 = 2 nM) and mTOR1 and mTOR2 (IC50 = 20 & 83 nM). PI-103 shows little activity against a wide array of protein kinases at 10µM. PI-103 blocks glioma proliferation by blocking the PI 3-K/Akt pathway in vitro and in vivo.
Solubility
Water: insoluble, DMSO: 10 mg/mL
Storage
Store dry at -20oC. Stock solutions should be stored frozen (-20oC).
