3-(4-Morpholinothieno[3,2-d]pyrimidin-2-yl)phenol is a selective inhibitor for the alpha-isoform of PI 3-Kinase (IC50: PI 3-Kalpha = 2 nM, PI 3-Kbeta = 16 nM, PI3-Kgamma = 660 nM, PI3KC2beta = 220 nM)). It showed >1000-fold selectivity vs. protein kinases such as PKA, KDR, PKCa, and E/CDK2 (IC50 = 91, 3.4, 466, 288 µM). It inhibited proliferation of A375 melanoma cells at 580 nM. Also known as PI3-K Inhibitor 2, PIK2.
Solubility
Water: insoluble, DMSO: 10 mg/mL
Storage
Store dry at 4oC. Stock solutions should be stored frozen (-20oC).
