Chemically modified tetracyclines show activity in mammalian cell pathways and diseases related to cancer, inflammation, and neurodegenerative pathways. 4-Demethylaminosancycline (CMT-3 or COL-3) acts as matrix metalloproteinase (MT-MMP) inhibitor. It has been studied in disorders of collagen destruction, excessive TNF activity, excessive nitric oxide activity, excessive IL-1 activity, excessiuve activity of elastase, bone loss, protein degradation, muscle wasting, collagen glycosylation, phospholipase A2 activity. In addition, CMT-3 has been investigated for the treatment of aneurysms, ulcerations, periodontal disease, diabetes, scleroderma, progeria, cancer, and diseases of bone marrow function and thrombocytopenia. Storage -20C or below References 1) Nip, L H, Uitto, V J, Golub, L M, ''Inhibition of epithelial cell matrix metalloproteinases by tetracyclines J. Periodontal Research, 1993, 28(5), 379-85. DOI:10.1111/j.1600-0765.1993.tb01082 2) Sasaki, T, Kaneko, H, Ramamurthy, N S, Golub, L M, ''Tetracycline administration restores osteoblast structure and function during experimental diabetes Anatomical Record, 1991, 231(1), 25-34. DOI:10.1002/ar.1092310105. 3) Schneider, B S, Maimon, J, Golub, L M, Ramamurthy, N S, Greenwald, R A, ''Tetracyclines inhibit intracellular muscle proteolysis in vitro Biochemical and Biophysical Research Communications, 1992, 188(2), 767-72 DOI:10.1016/0006-291X(92)91122-7. 4) Seftor, R E B, Seftor, E A, De Larco, J E, Kleiner, D E, Leferson, J, Stetler-Stevenson, W G, McNamara, T F, Golub, L M, Hendrix, M J C, ''Chemically modified tetracyclines inhibit human melanoma cell invasion and metastasis Clinical & Experimental Metastasis, 1998, 16(3), 217-225. 5) Protasoni, M., et al. (2018). Mitochondria as oncotarget: a comparison between the tetracycline analogs doxycycline and COL-3. Oncotarget 9(73): 33818-33831. Keywords: CMT-3, COL-3, COL-3 Compound, Incyclinide, NSC-683551
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