The non-mevalonate or MEP pathway for isoprenoid biosynthesis is essential in gram-negative some gram-positive bacteria plants and protozoa making it an attractive pathway to target for antibiotics since mammals use the mevalonate pathway to synthesize isoprenoids. IspF is the fourth step in the pathway and converts diphosphocytidyl-2-methylerythritol 2-phosphate into 2-methylerythritol 2 4-cyclodiphosphate (cMEPP). IspF inhibitor 1 (compound 3 in Geist et al.) has low micromolar activity (IC50 = 6.1-32 iM) against the recombinant enzymes and inhibits the growth of P. falciparum in a red blood cell assay.ReferenceJ.G. Geist et al a€Thiazolopyrimidine Inhibitors of 2-Methylerythritol 2 4-Cyclodiphosphate Synthase (IspF) from Mycobacteriumtuberculosis and Plasmodium falciparuma€ ChemMedChem 2010 5 1092-1101.
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301 302 38 34
CAS Nummer:
[1240789-72-3]
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