GloPIPs BODIPY TMR-PI(3,4,5)P3

Produktübersicht

• Artikelname: GloPIPs BODIPY TMR-PI(3,4,5)P3
• Artikelnummer: ECH-C-39M6A
• Hersteller Artikelnummer: C-39M6A
• Alternativnummer: ECH-C-39M6A-100UG,ECH-C-39M6A-50UG
• Hersteller: Echelon Biosciences
• Kategorie: Molekularbiologie

Produktbeschreibung

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2.

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GloPIPs are labeled at the sn-1 position with BODIPY-FL (505/513), BODIPY-TMR (544/574), or biotin. The sn-1 linkage in these labeled PIPs has been changed to a more stable amide from an ester. Results from experiments conducted at Echelon indicated that this minor chemical change did not have a significant effect in any of the applications tested. Bulk discounts available, please email echelon echelon-inc.com for information.

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Documents

Technical Data Sheet

Anwendungsbeschreibung

• Anwendungsbeschreibung: Categories: Lipids. Related: Fluorescent, PI(3\,4\,5)P3. Ship 1 : Shipping Temp. Ship 2: Dry ice or gel ice depending on destination