GloPIPs Biotin-PI(4,5)P2

Produktübersicht

• Artikelname: GloPIPs Biotin-PI(4,5)P2
• Artikelnummer: ECH-C-45B6A
• Hersteller Artikelnummer: C-45B6A
• Alternativnummer: ECH-C-45B6A-10UG,ECH-C-45B6A-50UG
• Hersteller: Echelon Biosciences
• Kategorie: Molekularbiologie

Produktbeschreibung

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4,5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PI(3,4,5)P3.

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GloPIPs are labeled at the sn-1 position with BODIPY-FL (505/513), BODIPY-TMR (544/574), or biotin. The sn-1 linkage in these labeled PIPs has been changed to a more stable amide from an ester. Results from experiments conducted at Echelon indicated that this minor chemical change did not have a significant effect in any of the applications tested.

Storage

-20C

Featured in Publications

1) Goksoy, E., Y.-Q. Ma, et al. (2008). Structural Basis for the Autoinhibition of Talin in Regulating Integrin Activation. Molecular cell 31(1): 124. 2) Michailidis, I., R. Rusinova, et al. (2011). Phosphatidylinositol-4,5-bisphosphate regulates epidermal growth factor receptor activation. Pflugers Archiv European Journal of Physiology 461(3): 387-397

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Documents

Technical Data Sheet

Anwendungsbeschreibung

• Anwendungsbeschreibung: Categories: Lipids. Related: Biotinylated, PI(4\,5)P2. Ship 1 : Shipping Temp. Ship 2: Dry Ice