GloPIPs BODIPY TMR-PtdIns(4,5)P2, C16

Produktübersicht

• Artikelname: GloPIPs BODIPY TMR-PtdIns(4,5)P2, C16
• Artikelnummer: ECH-C-45M16A
• Hersteller Artikelnummer: C-45M16A
• Alternativnummer: ECH-C-45M16A-100UG,ECH-C-45M16A-50UG
• Hersteller: Echelon Biosciences
• Kategorie: Molekularbiologie

Produktbeschreibung

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4,5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PI(3,4,5)P3.

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GloPIPs are labeled at the sn-1 position with BODIPY-FL (505/513), BODIPY-TMR (544/574), or biotin. The sn-1 linkage in these labeled PIPs has been changed to a more stable amide from an ester. Results from experiments conducted at Echelon indicated that this minor chemical change did not have a significant effect in any of the applications tested.

Excitation/Emission

542/574 nm

Storage

-20 C, protect from light

Featured in Publications

1) Golebiewska, U., M. Nyako, et al. (2008). Diffusion Coefficient of Fluorescent Phosphatidylinositol 4,5-bisphosphate in the Plasma Membrane of Cells. Mol Biol Cell 19(4): 1663-9. 2) Bethoney, K. A., M. C. King, et al. (2009). A possible effector role for the pleckstrin homology (PH) domain of dynamin. Proc Natl Acad Sci U S A 106(32): 13359-64. Bulk discounts available, please email echelon echelon-inc.com for information.

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Documents

Technical Data Sheet

Anwendungsbeschreibung

• Anwendungsbeschreibung: Categories: Lipids. Related: Fluorescent, PI(4\,5)P2. Ship 1 : Shipping Temp. Ship 2: Dry ice or gel ice depending on destination