INPP4A, active

Produktübersicht

• Artikelname: INPP4A, active
• Artikelnummer: ECH-E-8000
• Hersteller Artikelnummer: E-8000
• Alternativnummer: ECH-E-8000-2.5UG
• Hersteller: Echelon Biosciences
• Kategorie: Molekularbiologie

Produktbeschreibung

Human INPP4A with N-terminal 6-His tag Storage: Store product > -70 C. Enzyme is stable for at least 6 months at -70 C as undiluted stock Specificity: INPP4 selectively removes the phosphate from the 4 position of the inositol ring of PtdIns(3,4)P2 Molecular Weight: 107 kDa Specific Activity: request Certificate of Analysis (COA)

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Product Description Human INPP4A with N-terminal 6-His tag was expressed in Sf9 cells and purified using metal chelating chromatography. INPP4A is a magnesium-independent phosphatase involved in the phosphatidylinositol 3-kinase (PI3K) pathway. INPP4A and its isoenzyme INPP4B hydrolyze the 4 phosphate from the lipid second messenger phosphatidylinositol-3,4-bisphosphate (PI(3,4)P2) to form phosphatidylinositol-3-phosphate (PI(3)P). While little evidence supports its role as a tumor suppressor, INPP4A does suppress glutamate excitotoxicity in the central nervous system and is responsible for the Weeble mouse phenotype. A spontaneous frame shift mutation in the Inpp4a gene is present in the Weeble mouse resulting in selective neuronal loss in the cerebellum resulting, severe ataxia and early death. Product Keywords: Enzyme Aliases: INPP4A, inositol polyphosphate phosphatase 4A, inositol polyphosphate 4-phosphatase type I, type I inositol-3,4-bisphosphate 4-phosphatase

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Documents Technical Data Sheet

Anwendungsbeschreibung

• Anwendungsbeschreibung: Categories: Antibodies & Proteins. Related: Enzyme, Phosphatase. Ship 1 : Shipping Temp. Ship 2: Dry Ice