Geranyl S-Thiolodiphosphate (GSPP)
Artikelnummer:
ECH-I-S100
Produktübersicht
Artikelname:
Geranyl S-Thiolodiphosphate (GSPP)
Artikelnummer:
ECH-I-S100
Hersteller Artikelnummer:
I-S100
Alternativnummer:
ECH-I-S100-10MG,ECH-I-S100-1MG
Hersteller:
Echelon Biosciences
Kategorie:
Molekularbiologie
Produktbeschreibung
Geranyl thiolodiphosphate (GSPP) is an analog of GPP in which the non-bridging oxygen has been replaced by sulfur resulting in a less-reactive compound. GSPP is turned over by avian farnesyl diphosphate synthase (FPPase) more slowly than FPP and acts as a competitive inhibitor (KI = 24.8 µM). Featured In Publications 1. Phan, R. M. and C. D. Poulter (2001). Synthesis of (S)-Isoprenoid Thiodiphosphates as Substrates and Inhibitors. The Journal of Organic Chemistry 66(20): 6705. 2. Phan, R. M. and C. D. Poulter (2000). Synthesis of Geranyl S-Thiolodiphosphate. A New Alternative Substrate/Inhibitor for Prenyltransferases. Organic Letters 2(15): 2287. 3. Kuzuyama, T., J. P. Noel, et al. (2005). Structural basis for the promiscuous biosynthetic prenylation of aromatic natural products. Nature 435(7044): 983. 4. Koksal, M., W. K. W. Chou, et al. (2012). Structure of 2-Methylisoborneol Synthase from Streptomyces coelicolor and Implications for the Cyclization of a Noncanonical C-Methylated Monoterpenoid Substrate. Biochemistry 51(14): 3011. 5. Chen, M., et al. (2013). Mechanistic Insights from the Binding of Substrate and Carbocation Intermediate Analogues to Aristolochene Synthase. Biochemistry 52(32): 5441-5453. 6. Chen, M., et al. (2016). Probing the Role of Active Site Water in the Sesquiterpene Cyclization Reaction Catalyzed by Aristolochene Synthase. Biochemistry 55(20): 2864-2874. Bulk discounts available, please email echelon echelon-inc.com for information. Documents Technical Data Sheet
Anwendungsbeschreibung
Anwendungsbeschreibung:
Categories: Biochemical Reagents. Related: Isoprenoid, Isoprenoid Diphosphate. Ship 1 : Shipping Temp. Ship 2: Gel Ice
