FS-3 (LysoPLD / Autotaxin substrate)

Produktübersicht

• Artikelname: FS-3 (LysoPLD / Autotaxin substrate)
• Artikelnummer: ECH-L-2000
• Hersteller Artikelnummer: L-2000
• Alternativnummer: ECH-L-2000-100UG,ECH-L-2000-1MG,ECH-L-2000-200UG
• Hersteller: Echelon Biosciences
• Kategorie: Molekularbiologie

Produktbeschreibung

Echelons fluorogenic Autotaxin (ATX) substrate FS-3 (L-2000) is a doubly labeled analog of LPC wherin the fluorophore is quenched through intramolecular energy transfer. Hydrolysis of the substrate produces an increase in fluorescence.

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Autotaxin which has lysophospholipase D (lysoPLD) activity, cleaves choline from lysophosphatidylcholine forming lysophosphatidic acid (LPA), a potent mitogen that as been implicated in the pathophysiology of ovarian cancer. LysoPLD/ATX has been demonstrated to increase cell motility, neovascularization, proliferation, and aggressiveness of tumors and is upregulated in numerous cancer lineages (non-small cell lung , glioma, mammary carcinoma, renal cell carcinoma, hepatocellular carcinoma). In addition, dysregulation of the ATX/LPA pathway is central to the pathophysiology of idiopathic pulmonary fibrosis, rheumatoid arthritis, and other inflammatory diseases. Modulation of ATX activity through small-molecules is a currently underexplored target, but one with high potential for novel cancer and anti-inflammatory therapeutics.

Storage

-20 C

Solubility

5 mg / mL in H2O or MeOH

Featured in Publications

1) Ferguson, C. G., C. S. Bigman, et al. (2006). Fluorogenic phospholipid substrate to detect lysophospholipase D/autotaxin activity. Org Lett 8(10): 2023-6. 2) Baker, D. L., Y. Fujiwara, et al. (2006). Carba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasis. J Biol Chem 281(32): 22786-93. 3) Parrill, A. L., U. Echols, et al. (2008). Virtual screening approaches for the identification of non-lipid autotaxin inhibitors. Bioorg Med Chem 16(4): 1784-95. 4) Hoeglund, A. B., H. E. Bostic, et al. (2010). Optimization of a pipemidic acid autotaxin inhibitor. J Med Chem 53(3): 1056-66. 5) Tager, A.M. (2012) Autotaxin Emerges as a Therapeutic Target for Idiopathic Pulmonary Fibrosis: Limiting Fibrosis by Limiting Lysophosphatidic Acid Synthesis Am. J. Resp. Cell Mol. Biol. 47(5): 563-565. Notice to Purchaser: Echelon Biosciences products are sold for research and development purposes only and are not to be incorporated into products for resale without written permission from Echelon Biosciences. The compound FS-3 and its use in assaying for Lysophospholipase D activity are covered by Echelon Biosciences Inc. US patents 7,459,285 & 7,989,663. The purchase of this product includes a limited, non-transferable immunity from suit under the foregoing patent claims for using only this amount of product for the purchasers own internal research. For inquiries email busdev echelon-inc.com Bulk discounts available, please email echelon echelon-inc.com for information.

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Documents

Technical Data Sheet

Anwendungsbeschreibung

• Anwendungsbeschreibung: Categories: Biochemical Reagents. Related: Autotaxin, Fluorescent. Ship 1 : Shipping Temp. Ship 2: Gel Ice