ATX-Red AR-2
Artikelnummer:
ECH-L-2010
| Artikelname: |
ATX-Red AR-2 |
| Artikelnummer: |
ECH-L-2010 |
| Hersteller Artikelnummer: |
L-2010 |
| Alternativnummer: |
ECH-L-2010-100UG,ECH-L-2010-10UG,ECH-L-2010-50UG |
| Hersteller: |
Echelon Biosciences |
| Kategorie: |
Molekularbiologie |
ATX-Red AR-2 is an in vivo imaging probe for visualizing and measuring ATX activity. It is an analog of the autotaxin substrate lysophosphatidylcholine (LPC) and contains a near-infrared fluor (Licor IRDye 800CW) and quencher (Licor IRDye QC-1). The design is modeled after FS-3, a fluorogenic ATX substrate that is predictive of ATX activity. In the parent compound, fluorescence is quenched through intramolecular energy transfer, but when autotaxin cleaves ATX-Red AR-2, fluorescence increases. This activation mechanism is specific to autotaxin in vitro and in vivo.
Autotaxin which has lysophospholipase D (lysoPLD) activity, cleaves choline from lysophosphatidylcholine forming lysophosphatidic acid (LPA), a potent mitogen that as been implicated in the pathophysiology of ovarian cancer. LysoPLD/ATX has been demonstrated to increase cell motility, neovascularization, proliferation, and aggressiveness of tumors and is upregulated in numerous cancer lineages (non-small cell lung , glioma, mammary carcinoma, renal cell carcinoma, hepatocellular carcinoma). In addition, dysregulation of the ATX/LPA pathway is central to the pathophysiology of idiopathic pulmonary fibrosis, rheumatoid arthritis, and other inflammatory diseases. Modulation of ATX activity through small-molecules is a currently underexplored target, but one with high potential for novel cancer and anti-inflammatory therapeutics. Storage -20 C, protected from light Excitation/Emission 775/800 nm Featured in Publications Madan, D., C.G. Ferguson, et al. (2013) Non-Invasive Imaging of Tumors by Monitoring Autotaxin Activity Using an Enzyme-Activated Near-Infrared Fluorogenic Substrate PLoS One 8(11): e79065 Notice to Purchaser: Echelon Biosciences products are sold for research and development purposes only and are not to be incorporated into products for resale without written permission from Echelon Biosciences. The compound AR-2 and its use in assaying for Lysophospholipase D activity are covered by Echelon Biosciences Inc. US patents 7,485,259 & 7,989,663. The purchase of this product includes a limited, non-transferable immunity from suit under the foregoing patent claims for using only this amount of product for the purchasers own internal research. For inquiries email busdev echelon-inc.com Bulk discounts available, please email echelon echelon-inc.com for information.
Documents Technical Data Sheet |
| Anwendungsbeschreibung: |
Categories: Biochemical Reagents. Related: Autotaxin, Fluorescent. Ship 1 : Shipping Temp. Ship 2: Gel Ice |
