D-sn-1-O-oleoyl-2-O-methylglyceryl-3-phosphothionate (2R-OMPT)

Produktübersicht

• Artikelname: D-sn-1-O-oleoyl-2-O-methylglyceryl-3-phosphothionate (2R-OMPT)
• Artikelnummer: ECH-L-9318
• Hersteller Artikelnummer: L-9318
• Alternativnummer: ECH-L-9318-500UG
• Hersteller: Echelon Biosciences
• Kategorie: Molekularbiologie

Produktbeschreibung

2R-OMPT is a metabolically-stabilized analog of Lysophosphatidic Acid (LPA) which acts as potent agonist for the LPA3 receptor. Of the two enantiomers, (2S)-OMPT is more potent than (2R)-OMPT showing 5-20 fold more activity in calcium release from LPA3-transfected Sf9 and rat hepatoma Rh7777 cells. (2S)-OMPT is also more potent in inducing calcium release, IL-6 production, and MAPK and Akt phosporylation in OVCAR3 cells.

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Storage

-20 C

Featured in Publications

1) Qian, L., Y. Xu, et al. (2003). Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA3 receptor-selective agonist activity. J Med Chem 46(26): 5575-8. 2) Altman, M. K., V. Gopal, et al. (2010). Targeting melanoma growth and viability reveals dualistic functionality of the phosphonothionate analogue of carba cyclic phosphatidic acid. Mol Cancer 9: 140.

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Documents

Technical Data Sheet

Anwendungsbeschreibung

• Anwendungsbeschreibung: Categories: Biochemical Reagents. Related: Agonist, Lysophosphatidic Acid. Ship 1 : Shipping Temp. Ship 2: Gel Ice