Cardiolipin is an important component in prokaryotic and in eukaryotic inner mitochondrial membrane1. In humans, CL is made by cardiolipin synthase from phosphatitydlglycerol and cytidinedisphosphate-diacylglycerdol2. Due to its four acyl chains and small head group, CL can organize into domains which can be proton sinks, fill cavities at protein interfaces, stabilize protein oligomers, and participate in high-curvature membrane regions. Autoantibodies to CL have been found in patients with anti-phospholipid syndrome and lupus3.
Storage
-20 C or below, protect from light
Excitation/Emission
494/521 nm
References
1) Schlame M, Horvath L, Vigh L. Relationship between lipid saturation and lipid-protein interaction in liver mitochondria modified by catalytic hydrogenation with reference to cardiolipin molecular species. Biochem J 1990,265:79-85. 2. Houtkooper RH, Vaz FM. Cardiolipin, the heart of mitochondrial metabolism. Cell Mol Life Sci 2008,65:2493-506. 3. McNeil HP, Simpson RJ, Chesterman CN, Krilis SA. Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H). Proc Natl Acad Sci U S A 1990,87:4120-4.
