PPZ-A10

Produktübersicht

• Artikelname: PPZ-A10
• Artikelnummer: ECH-N-1410
• Hersteller Artikelnummer: N-1410
• Alternativnummer: ECH-N-1410-10MG, ECH-N-1410-25MG, ECH-N-1410-5MG
• Hersteller: Echelon Biosciences
• Kategorie: Molekularbiologie

Produktbeschreibung

PPZ-A10 is an ionizable lipid used for formulating lipid nanoparticles to deliver RNA in vitro and in vivo. PPZ-A10 LNPs preferentially delivered Cre mRNA to liver and spleen immune cells when injected intravenously into mice at concentrations as low as 0.3 mg/kg. PPZ-A10 LNPs containing RNA to generate chimeric antigen receptor macrophages were injected into a hepatocellular carcinoma mouse model resulting in decreased tumor burden and increased survival.