PI(3,4)P2 diC16

Produktübersicht

• Artikelname: PI(3,4)P2 diC16
• Artikelnummer: ECH-P-3416
• Hersteller Artikelnummer: P-3416
• Alternativnummer: ECH-P-3416-100UG,ECH-P-3416-1MG,ECH-P-3416-500UG
• Hersteller: Echelon Biosciences
• Kategorie: Molekularbiologie

Produktbeschreibung

PI(3,4)P2 diC16 (Phosphatidylinositol 3,4-bisphosphate diC16) is a synthetic, purified dipalmitoyl PI(3,4)P2. Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) is produced in stimulated cells by the action of phosphatidylinositol 3-kinases (PI3Ks) and/or lipid phosphatases (SHIP, TPTE, etc.). PI(3,4)P2 binds the pleckstrin homology (PH)-domain of AKT/PKB leading to cell survival and it also has an important role in podosome formation near focal adhesions.

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Featured in Publication

1. Dowler, S., R. A. Currie, et al. (1999). DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides. Biochem J 342(Pt 1): 7-12. 2. Karathanassis, D., R. V. Stahelin, et al. (2002). Binding of the PX domain of p47(phox) to phosphatidylinositol 3,4- bisphosphate and phosphatidic acid is masked by an intramolecular interaction. Embo J 21(19): 5057-68. 3. Stampoulis, P., T. Ueda, et al. (2012). Atypical membrane-embedded PI(3,4)P2 binding site on p47phox PX domain revealed by NMR. J Biol Chem(287): 17848-17859. 4. Ivarsson, Y., et al. (2013). Prevalence, Specificity and Determinants of Lipid-Interacting PDZ Domains from an In-Cell Screen and In Vitro Binding Experiments. PLoS ONE 8(2): e54581. 5. Aksnes, H., et al. (2017). Molecular Determinants of the N-Terminal Acetyltransferase Naa60 Anchoring to the Golgi Membrane. The Journal of biological chemistry 292: 6821-6837. Product Keywords: Dipalmitoyl Phosphatidylinositol 3,4-bisphosphate, PtdIns(3,4)P2 (16:0/16:0), PI(3,4)P2 C16, or PI34P2. Bulk discounts available, please email echelon echelon-inc.com for details.

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Documents

Technical Data Sheet

Anwendungsbeschreibung

• Anwendungsbeschreibung: Categories: Lipids. Related: diC16, PI(3\,4)P2. Ship 1 : Shipping Temp. Ship 2: Dry ice or gel ice depending on destination